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Kulkarni, Amol A.
- A Stability-Indicating HPTLC Method for Estimation of Nadifloxacin in Topical Cream
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1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharahtra, IN
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharahtra, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 1, No 1 (2010), Pagination: 25-29Abstract
The present work describes a stability-indicating HPTLC method for analysis of nadifloxacin in topical cream. The separation was carried out on Merck precoated silica gel aluminium plate 60 F254 using Chloroform: Methanol: Ammonia (4.3: 4.3: 1.4 v/v/v) as mobile phase. The densitometric scanning was carried out at 296 nm. Response was found to be linear in the concentration range of 50-300 ng /band with correlation coefficients (r2 = 0.9979). The method was validated as per ICH guidelines. The method was successfully applied for the analysis of drugs in pharmaceutical formulation. Nadifloxacin was subjected to forced degradation by acid, alkali, neutral, oxidation, dry heat, wet heat, sunlight, UV light. The degradation products were well resolved from the pure drug with significantly different RF values.Keywords
Nadifloxacin, HPTLC, Validation, Stability Studies.- Spectrophotometric Methods for Simultaneous Estimation of Dexibuprofen and Paracetamol
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Authors
Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra, IN
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra, IN